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Why One Truth Serum with TAM-818 works

Telomeres and Aging

OT (7 of 16)We age because our cells age.

And our cells age because our telomeres get short.

Telomeres are the “end part” of our chromosomes – a long, repetitive sequence of DNA in our genome, so long that it can be stained and seen under a microscope. Every time our cells divide, our telomeres get a little shorter, and every time they shorten, our cells age. That’s the central cause of ageing.

Aging is programmed; we age at a somewhat predictable and constant rate. Therefore, it stands to reason that humans must have a “clock” ticking inside us – some kind of timing mechanism counting us down to self- destruction. Biologists (and before them, philosophers) have always reasoned that this may be the case, but at the time, no one could find the mechanism.

The telomere is that mechanism. It is the “clock” of aging that ticks inside every dividing cell of the human body, and in learning how to wind that clock backwards lays the cure for human aging.

The End Replication Problem

The Nature of DNA Replication

When a cell divides, the genetic material inside that cell needs to be copied. This process is called DNA replication. The limitation on cell division are rooted in the very nature of DNA replication. The enzymes that replicate a strand of DNA are unable to continue replicating all the way to the end, which causes the loss of some DNA.

As an analogy, think of a DNA strand as a long row of bricks, and of DNA replication as a bricklayer walking backwards on top of a brick wall laying a new layer on top of that row. When the end of the wall is reached, the bricklayer finds himself standing on top of the brick he’s supposed to replicate. Since he can’t put down a brick where his feet are, he steps back and falls off the wall—leaving the very end of the wall bare. As a result, the new copy of the wall is a bit shorter than the original.

Just like this brick wall was copied imperfectly, our DNA is unable to perfectly copy itself. When a strand is replicated, the new strand is shorter than the old strand.

bricks_1 copyIf we lost portions of the information encoded in our DNA every time it replicated, human life would be impossible. Our cells couldn’t even divide enough times to allow us to be born before they went haywire due to the missing information, failing to perform their basic functions. This is one of the reasons the telomere is essential. Its long, repetitive sequences of DNA give us a “buffer” of genetic material that contains no (essential) information, so it can be safely consumed as part of the normal DNA replication process.

Most of the cells in our body are in a constant state of division. Every system in our body suffers damage and needs constant upkeep, and cell division is the body’s primary method of performing that upkeep. Many of our cells divide about yearly to keep our organs functioning. And with every division, the telomere shortens a little more, and a little more, until it becomes so short that any further division would start eating into our genetic information and mutations that can lead to cell death.

Telomeres, like all DNA, are made up of units called nucleotides, arranged like beads on a string. In the human genetic code, all our genetic information is coded using four nucleotides: adenine, guanine, cytosine, and thymine. The nucleotides in human telomeres are arranged in the repeating sequence TTAGGG (two thymine nucleotides, one adenine nucleotide, and three guanine nucleotides). This sequence is repeated thousands of times in tandem in every telomere. When we are first conceived, the telomeres in our single-cell embryos are approximately 15,000 nucleotides long. Our cells divide rapidly in the womb, and by the time we are born, our telomeres have decreased in length to approximately 10,000 nucleotides. They shorten throughout our lifetime, and when they reach an average of about 5,000 nucleotides, our cells cannot divide any further, and we die of old age.

Activating telomerase slows down and reverses aging.

Obviously, there must be a way for our bodies to re-lengthen telomeres. Otherwise, our sperm and egg cells would contain telomeres the same length as the rest of our cells, which would yield embryos that would be biologically as old as we are. Because so much cell division takes place in the womb, our children would then be born much older than us. Humanity could not continue to exist for more than a generation or two if this were the case.

However, our reproductive cells do not exhibit telomere shortening, and show no signs of aging. They are our germ line – the same one that has been dividing since the beginning of life on this planet. And this germ line is, essentially, immortal.

The reason this line of cells is immortal is that our reproductive cells produce an enzyme called telomerase. Telomerase has one primary function: to act like an assembly rna_templateline that adds nucleotides to the ends of our chromosomes, thereby lengthening our telomeres.

In a cell that expresses telomerase, telomeres are lengthened as soon as they shorten; it’s as though every time the “telomere clock” inside our cells ticks once, telomerase pushes the hands of the clock back one tick.

Telomerase works by filling the “gap” left by DNA replication. Returning to the analogy of the bricklayer that can’t lay the last brick on the brick wall, telomerase would be like an angel that flies in and puts the last brick in place.

Proof of Concept

Telomere Length Therapy

 Shortly after discovering human telomerase, Dr Bill Andrews and his team at Geron Corporation added the gene for telomerase to a line of normal human cells in 1998.

They used a plasmid, a circular ring of DNA that can integrate itself into a chromosome under certain circumstances. The team found that inserting telomerase into a human cell produced a line of cells that was able to divide indefinitely without entering replicative senescence (cell death) as an unmodified cell culture would. This demonstrated that normal human cell lines could be made immortal.

diagram_2

TAM-818 is the world’s strongest telomerase inducer.

Sierra Sciences, using a robotically-driven high-throughput drug screening effort, has discovered over nine hundred compounds in thirty-nine distinct drug (medicinal) families that induce the expression of telomerase in normal cells. They randomly screened over 250,000 compounds, and found a chemical that induced about a minor amount of the telomerase expression found in some immortal cell lines. In a matter of a few months, they took that information from those random hits and used it to design new chemicals, one of which was almost three times as potent. TAM- 818!

So how does One Truth Serum work?

So how does One Truth Serum work? As mentioned before TAM-818 is the world’s strongest telomerase inducer ever created and One Truth is the only skincare range in the world to contain this ingredient. One Truth Serum works on the skin in the same way as the brick-layer demonstrates in cells. When the brick is missing along comes TAM-818 and replaces the brick. Scientific testing at Sierra Sciences proves that the replacement brick is 16% of the brick that is missing. In other words the telomerase inducing action is not strong enough yet to replace allof the lost DNA but it will slow the ageing process by 16%.

Real world results

Tried. Tested. The Truth

Although we have scientifically proven in vitro to slow the ageing process by 16% our real world testing on actual people showed a whole different story. Volunteers showed visible improvements to their wrinkles, pigmentation and tone of their skin, not just that they were ‘ageing slower’ as that is difficult to see in a short period of time. All volunteers showed reversals of major signs of ageing in as little as 2 weeks (measured clinically).

After only 30 days Clinical Trials at Abich Laboratories in Italy showed:

Skin Firmness improved by an average of 20.33% and Skin Elasticity by 8.33%.

Skin Smoothness improved by 12.53% on the forehead and 9.63% in the eye area.

Forehead wrinkles decreased by 14.04% and crows feet wrinkles decreased by 11.07%.

Our clinical, medically run tests were performed at Abich Laboratories in Italy and carried out on 100 volunteers over a one month period with measurements and results taken half way at day 15.

This testing is over and above any ‘recommended’ number of volunteers in order to prove, without a doubt, the efficacy of One Truth.

Of these 100 volunteers:

(all women, aged between 36-65 years of age)

90 noticed and improvement in skin roughness/depth of wrinkles with 2 weeks.

92 noticed improvement in skin hydration levels within 2 weeks.

80 said they would buy the product once on the market.

0 volunteers had any adverse reactions to One Truth Serum.

In a Nut Shell

How it will work

In a nutshell, telomerase stops your cells from ageing and can reverse ageing. If your skin cells don’t age or indeed get younger they will behave like younger skin. Younger skin produces collagen, elastin and has an abundance of hyaluronic acid. It doesn’t wrinkle with usage, isn’t prone to pigmentation or ‘age spots’ and has a much more even tone than aged skin.

Full ingredients listing:

Water, Jojoba Esters, Macadamia integrifolia Seed Oil, Ethyl Macadamiate, Isoamyl Laurate, Sodium Acrylates Copolymer, Glycerin, TAM 818, Helianthus Annuus (Sunflower) Seed Oil,Caprylhydroxamic acid, Glyceryl Caprylate , Hydrogenated Polyisobutene, Lecithin, Phospholipids, Polyglyceryl-6 Caprylate, Polyglyceryl-10 Stearate, Propanediol, Tocopherol, Isopropyl Myristate, Citric Acid, Potassium Sorbate, Sodium Phytate, Fragrance (EcoCertified), Limonene, Linalool.